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Week 1 NFL Game Odds for Each Matchup

Check out the betting odds for every game in the NFL's opening week following the schedule's unveiling on May 14, 2025. These include NFL Week 1 spreads, moneylines, and totals.

,   and  ASMedia
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Check out the NFL Week 1 betting odds for every game following the scheduling announcement on May...
Check out the NFL Week 1 betting odds for every game following the scheduling announcement on May 14, 2025. The spreads, moneylines, and totals for all 16 games are available now.

Week 1 NFL Game Odds for Each Matchup

Get Ready, Football Fans! NFL Week 1 Odds are Out

Hey there, sports enthusiasts! This week's football excitement is just around the corner, and the NFL Week 1 odds are kicking off with a bang! Let's dive right into the action and see what teams have the best chances of taking home a victory.

First off, the Philadelphia Eagles have high spirits beginning Week 1 as they've opened as touchdown favorites over their rivals, the Dallas Cowboys[1]. That's right; the Eagles will be pumped to get back on the field, and they'll be looking to make a statement in the first battle of the season against the Cowboys[2].

But the Eagles won't hold the title for the biggest spread alone. The Washington Commanders and the Tennessee Titans have tied for the game with the highest point spread of 7.5 points each[2]. In the early window on Sunday, September 8th, the Commanders host the New York Giants with a 7.5-point advantage. Meanwhile, the Denver Broncos, with #1 draft pick Cam Ward set to make his first career start, are also (7.5-point) home champs in the matchup with the Tennessee Titans[2].

Surprisingly, Ward is the second-favorite to land the NFL Offensive Rookie of the Year award, just behind Raiders running back Ashton Jeanty[2].

The Baltimore Ravens vs Buffalo Bills matchup boasts the highest total on the board, with a points total of 51.5[2]. Ravens vs Bills is the only Week 1 game pitting two of the top-five favorites in the Super Bowl odds. Baltimore is the second-favorite team at +700, with the Bills close behind at +750[2].

Unfortunately, the game with the lowest total points for Week 1 is the one you probably saw coming: the Steelers vs Jets in East Rutherford, with a total of 41.5 points[2]. This low total is in stark contrast to all the other games on the board, which have totals of 43.5 or higher[2].

Bookmark our NFL odds page to keep track of any changes! And don't forget to check out our NFL public betting splits page for game-by-game bet and money percentages[4].

Lock in your favorites' odds before they change!

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Enrichment Data:The current NFL Week 1 odds for the New York Giants vs Washington Commanders game are as follows:

  • Spread: Giants +7.5, Commanders -7.5
  • Moneyline: Giants +270, Commanders -340
  • Total (Over/Under): 45.5 points

The game is scheduled for Sunday, September 7, 2025, at 1:00 PM ET in Landover, MD. The Giants are early underdogs, with a 7.5-point handicap, reflecting their struggling performance last season and Washington being the favored team at home.[1][3][5]

  1. Preparations for NFL Week 1 are underway, with the New York Giants and Washington Commanders facing off under the 7.5-point spread for the Giants.
  2. In the NFL Week 1 sports analysis, the Commanders are the home team favorites, while the Giants are the underdogs, according to the moneyline odds of -340 for the Commanders and +270 for the Giants.
  3. The total points for the game between the New York Giants and Washington Commanders have been set at 45.5 points, according to the NFL odds for this matchup.
  4. Interestingly, despite the Giants being underdogs in this game, the Raiders' running back Ashton Jeanty is favored to win the NFL Offensive Rookie of the Year award, with second-favorite honors going to Cam Ward of the Denver Broncos.
  5. For both sports-analysis enthusiasts and bettors, it's crucial to keep track of the NFL Week 1 odds and moneyline shifts, as they can significantly impact the outcome of the games and the wagers made on them.

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