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NFL Week 12 surprises: Underdogs thrive as 49ers game steals the spotlight

Week 12 defied expectations—underdogs shined, and the 49ers game became the talk of the league. Will Mayfield’s injury rewrite Week 13’s story?

In this image there are people playing american football. In the background of the image there are...
In this image there are people playing american football. In the background of the image there are trees. There is a house. There are cars. At the bottom of the image there is grass.

NFL Week 12 surprises: Underdogs thrive as 49ers game steals the spotlight

Week 12 in the NFL saw underdogs perform well against the spread, while Opta AI’s projections proved mostly accurate. Meanwhile, injuries and coaching changes are shaping the outlook for Week 13. The Panthers-49ers matchup has drawn particular attention from bettors and analysts alike.

In Week 12, favourites dominated straight-up with a 9-3 record, but underdogs covered the spread in eight of 12 games—including five that lost outright. Opta AI’s projections were close, predicting 18-9 on passing yards (actual: 37-33), 37-33 on rushing yards (actual: 74-68), and 74-68 on receiving yards (actual: 74-68).

The Panthers-49ers game remains a focal point for bettors, with differing opinions on the spread. Mayfield’s injury and Kelly’s departure add further variables to Week 13’s early lines. Analysts and sportsbooks will continue adjusting as more 49ers news emerges.

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