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MLB Matchup Forecast: Brewers vs. Cubs, Predicted Winner, Betting Odds, and Top Picks for August 18 by a Reliable Model

Simulation of 10,000 games on our website predicts MLB choices for the Monday afternoon Game 1 encounter between Milwaukee Brewers and Chicago Cubs at Wrigley Field in Chicago

Baseball Game Preview for August 18, 2025: Milwaukee Brewers vs. Chicago Cubs - Forecasted...
Baseball Game Preview for August 18, 2025: Milwaukee Brewers vs. Chicago Cubs - Forecasted Outcomes, Odds, and Prime Picks from a Reliable Model

MLB Matchup Forecast: Brewers vs. Cubs, Predicted Winner, Betting Odds, and Top Picks for August 18 by a Reliable Model

Chicago Cubs and Milwaukee Brewers Prepare for Closely Contested Series

The Chicago Cubs and Milwaukee Brewers are set to square off in a five-game series starting on Monday, with the first game being a day-night doubleheader at Wrigley Field. This National League Central matchup promises to be a closely contested one, as indicated by the predictions and betting advice.

In Friday's game against the Cincinnati Reds, Sal Frelick of the Brewers showed his offensive prowess, going 2-for-4 with a walk. Meanwhile, Nico Hoerner of the Cubs has been a consistent performer this season, boasting a batting average of .293 with 20 doubles, 3 triples, 48 RBI, and 22 stolen bases.

According to the latest odds from DraftKings Sportsbook, the Cubs are a -128 favorite on the money line for the series opener. The over-under for the game is set at 8.5 runs.

MLB Predictions & Betting Advice

The game is very balanced, with slight leanings towards the Cubs at home. Bettors might consider the Cubs moneyline and run line value, and target strikeout props for their pitchers. The total run line around 7.5-8.5 with an over play is also recommended given the offensive tendencies.

Cade Horton is expected to start for the Chicago Cubs in Game 1, with a record of 7-3 and a 3.07 ERA. On the other side, Freddy Peralta, with a record of 14-5 and an ERA of 2.90, will take the mound for the Brewers.

The teams have split their eight meetings this season, with the Brewers currently holding a 4-4 record. The Cubs, who are 38-23 on their home field in 2025, will be looking to capitalize on their home advantage. The Brewers, who have a strong road record of 36-25, will aim to continue their success away from home.

Recent form suggests that both teams are in good form. The Brewers ended a 14-game winning streak but remain strong on the road, while the Cubs have won their last two games.

Key Players to Watch

In the past 10 games, both Frelick and Hoerner have had multiple-hit performances. Frelick, the right fielder for the Brewers, has a batting average of .294 this season with 13 doubles, 3 triples, 9 homers, and 18 stolen bases. Hoerner, the second baseman for the Cubs, has a batting average of .293 with 20 doubles, 3 triples, 48 RBI, and 22 stolen bases.

The pitching matchups to watch include Peralta for the Brewers versus Horton for the Cubs in Game 1, or earlier in the series, Patrick for the Brewers versus Boyd for the Cubs. Specific props like Boyd’s over 5.5 strikeouts are seen as good value bets.

The first pitch for Game 1 is set for 2:20 p.m. ET from Wrigley Field in Chicago. This series promises to be an exciting one, with both teams showcasing their strengths and looking to gain an edge in the National League Central race.

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