'Forever chemicals' may accelerate biological ageing in middle-aged men, study reveals
A new study has found that exposure to PFAS—often called 'forever chemicals'—may speed up biological ageing in men. Researchers analysed 23 different PFAS compounds and discovered the strongest links in men aged 50 to 65. These chemicals, which linger in the body for years, are now under closer scrutiny for their long-term health effects.
The study focused on men between 50 and 64, where certain PFAS chemicals showed the clearest connection to accelerated epigenetic ageing. Perfluorhexanesulfonic acid (PFHxS), perfluorobutanesulfonic acid (PFBS), and perfluorohexanoic acid (PFHxA) were among the most strongly linked. Higher levels of PFNA and PFOSA also predicted faster biological ageing in this age group.
PFAS exposure is widespread, with an estimated 98% of Americans carrying traces in their blood. These chemicals break down extremely slowly, earning their 'forever' label. While complete avoidance is impractical, experts advise reducing exposure where possible.
The effects of PFAS may differ between men and women. Women tend to eliminate some PFAS faster due to pregnancy, breastfeeding, and menstrual cycles. In men, however, the chemicals have been tied to lower testosterone, poorer sperm quality, and higher risks of testicular and kidney cancers. The endocrine system, which regulates hormones and metabolism, appears particularly vulnerable to disruption.
Researchers stress that regulatory action and environmental cleanup are essential to lowering risks. Without intervention, the long-term health impacts of PFAS could persist for decades.
The findings highlight a clear pattern: middle-aged men face the greatest risk of accelerated biological ageing from PFAS exposure. While these chemicals are nearly impossible to avoid entirely, targeted policies and cleanup efforts could help reduce their impact. Further research may clarify why men are more affected and how to mitigate the risks.
