Competitive Clash Between Illinois and Indiana Examined and Anticipated - September 20, 2025
On Saturday, September 20th, at Memorial Stadium in Bloomington, Indiana, the highly anticipated matchup between the Indiana Hoosiers and the Illinois Fighting Illini is set to take place. The game will be broadcast on NBC, with kickoff scheduled for 7:30 pm ET.
The Indiana Hoosiers, currently ranked 25th in the nation in run frequency (60.9%), are allowing only 7.3 points per game this season. Their star quarterback, Fernando Mendoza, is being touted as a future No. 1 draft pick, although the source of this selection remains undisclosed.
Indiana has a massive home-field advantage, and the spread for the game favors them by 6 points, with odds of -110 for Indiana and the same for Illinois. As of Wednesday, September 17th, the moneyline for the game favors Indiana with odds of -238, while Illinois has odds of +195.
The Illinois Fighting Illini, on the other hand, are led by quarterback Luke Altmyer, described as a standard college quarterback. The team is giving up 7.7 points per game, a number that is less impressive due to not having played anyone of significant stature.
The total points for the game is set at 52.5, with odds of -110 for Over 52.5 and the same for Under 52.5. Steve Makinen's projected score for the game is Indiana 27.5 to Illinois 22.7, with his estimated total for predicting the line for this game being 50.1, which is below the available number of 52.5.
The Under has been a trend for both teams in recent games. For the Illini, the Under is 9-2-1 when they have played teams with winning percentages of 75.0% or higher. The Under is also 11-5 in the 16 road games that Illinois has played as a road underdog under Bret Bielema.
For those interested in best bets for the game, the Pro Picks page offers a wealth of information. Additionally, for more college football betting content, be sure to check out the Week 4 College Football Betting Hub.
This game is considered a significant college football matchup, and fans are eagerly awaiting the outcome. Let's see who will come out on top in this exciting encounter!
